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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Related Experiment Video

Updated: Jul 9, 2025

Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction
06:19

Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction

Published on: November 6, 2019

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Invasive Malassezia Infections.

Masato Tashiro1,2, Takahiro Takazono1,3, Koichi Izumikawa1,2

  • 1Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences.

Medical Mycology Journal
|November 29, 2023
PubMed
Summary

Malassezia fungi, common on skin, can cause invasive infections, especially in neonates via catheters. Unlike other fungal infections, risk factors like neutropenia are not associated.

Keywords:
diagnosisepidemiologyinvasive Malassezia infectionstreatment

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Area of Science:

  • Mycology
  • Dermatology
  • Infectious Diseases

Background:

  • Malassezia species are lipophilic, dimorphic fungi part of the normal human skin microbiota.
  • They can form biofilms and cause superficial mycoses like folliculitis.
  • Rarely, Malassezia causes invasive infections, particularly catheter-associated bloodstream infections in neonates.

Purpose of the Study:

  • To review the characteristics, diagnosis, and management of invasive Malassezia infections.
  • To highlight unique risk factors and clinical presentations.
  • To address the need for evidence-based treatment guidelines.

Main Methods:

  • Literature review of invasive Malassezia infections.
  • Analysis of diagnostic methods including histology, cytology, and culture.
  • Summary of current management strategies for catheter-related infections.

Main Results:

  • Invasive Malassezia infections are infrequent but serious, especially in neonates.
  • Neutropenia and broad-spectrum antibiotics are not typical risk factors.
  • Diagnosis relies on identifying yeasts in sterile sites.
  • Prognosis is generally favorable, but treatment guidelines are limited.

Conclusions:

  • Invasive Malassezia infections require prompt diagnosis and management, including catheter removal and antifungal therapy.
  • Further research is needed to establish evidence-based treatment protocols.
  • Understanding unique risk factors aids in preventing and treating these infections.