Study on Improving the Performance of Traditional Medicine Extracts with High Drug Loading Based on Co-spray Drying...

Area of Science:

• Pharmaceutical Technology
• Materials Science

Background:

• Liuwei Dihuang (LWDH) powder exhibits poor flowability and compactibility, hindering direct compaction (DC) tablet formulation.
• Developing modified particles is crucial for enhancing powder properties in pharmaceutical manufacturing.

Purpose of the Study:

• To engineer modified Liuwei Dihuang (LWDH) particles with enhanced flowability and compactibility using co-spray drying.
• To investigate the preparation mechanism and direct compaction (DC) properties of these modified particles.
• To prepare and evaluate high-drug-loaded tablets from the modified LWDH particles.

Main Methods:

• Co-spray drying was employed to prepare porous particles (Ps), core-shell particles (CPs), and porous core-shell particles (PCPs).
• Polyvinylpyrrolidone (PVP K30) and hydroxypropyl methylcellulose (HPMC E3) were used as shell materials.
• Sodium bicarbonate and ammonium bicarbonate served as pore-forming agents.

Main Results:

• Porous core-shell particles (PCPs) demonstrated the most significant improvement in DC properties compared to Ps and CPs.
• The shell structure enhanced fluidity, while the porous structure provided greater compaction space.
• Co-spray drying successfully created composite structures with improved particle characteristics.

Conclusions:

• Co-spray drying is an effective method for developing modified LWDH particles with superior flowability and compactibility.
• Porous core-shell particle design offers a promising strategy for improving direct compaction properties.
• This approach facilitates the production of high-drug-loaded tablets with improved manufacturability.