Nuclear localization signal-tagged systems: relevant nuclear import principles in the context of current therapeutic
Ritabrita Goswami1, Aarohi Gupta1, Olga Bednova2
1Department of Chemistry, University of Massachusetts, Massachusetts, USA. rotello@chem.umass.edu.
Abstract:
Nuclear targeting of therapeutics provides a strategy for enhancing efficacy of molecules active in the nucleus and minimizing off-target effects. 'Active' nuclear-directed transport and efficient translocations across nuclear pore complexes provide the most effective means of maximizing nuclear localization. Nuclear-targeting systems based on nuclear localization signal (NLS) motifs have progressed significantly since the beginning of the current millennium. Here, we offer a roadmap for understanding the basic mechanisms of nuclear import in the context of actionable therapeutic design for developing NLS-therapeutics with improved treatment efficacy.
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