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Updated: Jul 9, 2025
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Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
16.9K
Understanding cellular senescence: pathways involved, therapeutics and longevity aiding
Ashish Kumar1, Kavitha Thirumurugan1
1Pearl Research Park, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, India.
Cell Cycle (Georgetown, Tex.)
|November 30, 2023
Summary
Cellular senescence, an irreversible cell cycle arrest, accumulates with age, driving inflammation and age-related diseases. This review explores senescence pathways and therapeutic strategies targeting senescent cells for healthier aging.
Area of Science:
- Cellular Biology
- Gerontology
- Molecular Medicine
Background:
- Normal somatic cells have finite divisions, regulated by surveillance checkpoints.
- Stress inducers like oxidative stress and telomere attrition trigger cell cycle arrest for repair.
- Cellular stress leads to either reversible quiescence or irreversible senescence.
Purpose of the Study:
- To review senescence-associated pathways.
- To understand cellular senescence as a driver of aging.
- To discuss therapeutic strategies targeting senescent cells.
Main Methods:
- Literature review focusing on molecular pathways of senescence.
- Analysis of senescence-associated secretory phenotype (SASP).
- Examination of therapeutic interventions for senescent cell clearance.
Main Results:
- Senescence is an irreversible process accumulating with age.
- Accumulated senescent cells contribute to inflammation and age-related disorders.
- Targeting senescent cells and their secretions shows therapeutic potential.
Conclusions:
- Cellular senescence is a key mechanism in aging.
- Understanding senescence pathways is crucial for developing anti-aging therapies.
- Therapeutic strategies aimed at senescent cells offer promise for mitigating age-related diseases.
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