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Emerging roles for tumor stroma in antigen presentation and anti-cancer immunity

Athanasios Papadas1,2, Yun Huang1,2, Alexander Cicala1,2

  • 1Division of Blood and Marrow Transplantation, Department of Medicine, University of California San Diego (UCSD), La Jolla, CA, U.S.A.

Biochemical Society Transactions
|November 30, 2023
PubMed
Summary

Tumor stroma, not just a barrier, actively shapes immune responses by instructing antigen-presenting cells (APCs). This stromal control over APCs is crucial for effective CD8+ T cell activation against cancer.

Keywords:
T-cellsantigen presentationcancerdendritic cellsstromavaccines

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