Association of Cardiovascular Events with COVID-19 Vaccines Using Vaccine Adverse Event Reporting System (VAERS): A
Mohd Amir1, S Latha2, Ruchika Sharma3
1Department of Clinical Research, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi, 110017, India.
Insights
COVID-19 vaccines show a statistically significant association with cardiovascular events, according to VAERS data analysis. Further research is needed to confirm causality between these vaccines and heart conditions.
Area of Science:
- Cardiology
- Vaccinology
- Public Health
Background:
- COVID-19 vaccines are vital for pandemic control.
- Emerging reports suggest a link between COVID-19 vaccines and cardiovascular events.
- The precise nature of this association remains unclear.
Purpose of the Study:
- To investigate the potential association between COVID-19 vaccines and cardiovascular events.
- To analyze adverse event data for signals of cardiovascular risk following vaccination.
Main Methods:
- Utilized the COVID-19 Vaccine Knowledge Base (Cov19VaxKB) tool.
- Queried the Vaccine Adverse Event Reporting System (VAERS) database.
- Employed proportional reporting ratio (PRR) and chi-squared tests to assess statistical significance.
Main Results:
- Identified 33,754 cardiovascular event cases linked to COVID-19 vaccines in VAERS.
- Observed associations across various age groups and genders.
- Disproportionality measures indicated a statistically significant signal.
Conclusions:
- A signal of cardiovascular events associated with COVID-19 vaccines was detected.
- The study highlights the need for further investigation into causality.
- Continued monitoring of vaccine safety is crucial.
Background:
COVID-19 vaccines have played a crucial role in reducing the burden of the global pandemic. However, recent case reports have indicated the association of the COVID- 19 vaccines with cardiovascular events but the exact association is unclear so far.
Objective:
Therefore, the objective of the current study is to find out the association of cardiovascular events with COVID-19 vaccines.
Methods:
The COVID-19 Vaccine Knowledge Base (Cov19VaxKB) tool was used to query the Vaccine Adverse Event Reporting System (VAERS) database. The proportional reporting ratio [PRR (≥2)] with associated chi-squared value (>4), and the number of cases > 0.2% of total reports, was used to assess the association of COVID-19 vaccines with cardiovascular events.
Results:
A total of 33,754 cases of cardiovascular events associated with COVID-19 vaccines were found in the Cov19VaxKB tool. The cases were observed in different age groups (18-64, and 65 years and above) and gender. The disproportionality measures indicate a statistically significant association between cardiovascular events and COVID-19 vaccines.
Conclusion:
The current study identified a signal of various cardiovascular events with the COVID-19 vaccines. However, further causality assessment is required to confirm the association.
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