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Serum gastrin concentrations in dogs with primary hyperparathyroidism
Julieann Vose1, Jared Jaffey2, Camille Akin1
1Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA.
Mild hypergastrinemia occurs in dogs with primary hyperparathyroidism (PHPT), but it is not linked to gastrointestinal signs or calcium levels. Treatment for PHPT does not alter gastrin concentrations.
Area of Science:
- Veterinary Medicine
- Endocrinology
- Canine Health
Background:
- Hypercalcemia is linked to hypergastrinemia in humans.
- Hypergastrinemia may cause gastrointestinal signs in dogs with primary hyperparathyroidism (PHPT).
Purpose of the Study:
- Determine if hypergastrinemia occurs in dogs with PHPT.
- Assess correlations between ionized calcium (iCa), parathyroid hormone (PTH), and serum gastrin.
- Evaluate if gastrin concentrations decrease after PHPT management.
Main Methods:
- Studied 151 dogs with PHPT at diagnosis and 24 treated dogs.
- Excluded dogs with azotemia, concurrent disease, or on acid suppressants.
- Measured serum gastrin, iCa, and PTH pre- and post-treatment.
Main Results:
- 17.9% of PHPT dogs had elevated gastrin; concentrations were not correlated with iCa or PTH.
- PHPT treatment reduced PTH and iCa but did not significantly change gastrin levels.
- No difference in hypergastrinemia prevalence between dogs with and without GI signs.
Conclusions:
- Mild hypergastrinemia can occur in dogs with PHPT.
- This finding is independent of gastrointestinal signs.
- PHPT management does not affect gastrin concentrations.
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