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Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications
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Biomedical Application of Decellularized Scaffolds.

Fang Zhang1, Huimin Gao1, Xuefeng Jiang1

  • 1National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.

ACS Applied Bio Materials
|November 30, 2023
PubMed
Summary

Decellularized scaffolds, derived from natural tissues, offer superior biocompatibility for tissue engineering. This review highlights their preparation, modification, and applications in regenerating organs and tissues, reducing rejection risks.

Keywords:
biomaterialsbiomedical applicationdecellularized scaffoldpolymertissue engineering

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Materials Science

Background:

  • Tissue loss and organ failure are significant global health challenges.
  • Current artificial organs from synthetic polymers face limitations like immune rejection.
  • Biomimetic decellularized scaffolds show promise due to biocompatibility and adaptability.

Purpose of the Study:

  • To comprehensively review the recent applications of decellularized scaffolds in tissue engineering and biomedicine.
  • To discuss the preparation, modification, and construction of artificial tissues using these scaffolds.
  • To provide a reference for advancing decellularized scaffold research and applications.

Main Methods:

  • Literature review of decellularized scaffold applications.
  • Analysis of preparation and modification techniques.
  • Evaluation of scaffold use in artificial tissue construction and biomedical applications.

Main Results:

  • Decellularized scaffolds exhibit excellent biocompatibility, facile modification, and organism adaptability.
  • They are effectively used in constructing various artificial tissues.
  • Applications span diverse biomedical fields, demonstrating significant potential.

Conclusions:

  • Decellularized scaffolds represent a key advancement in tissue engineering.
  • Their biomimetic nature minimizes adverse immune responses.
  • Further research will enhance their role in organ regeneration and treating tissue loss.