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Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Related Experiment Video

Updated: Jul 9, 2025

Mouse Kidney Transplantation: Models of Allograft Rejection

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Emerging phenotypes in kidney transplant rejection.

Michael Mengel¹, Benjamin A Adam

¹Department of Laboratory Medicine & Pathology, University of Alberta, Edmonton, Alberta, Canada.

Current Opinion in Organ Transplantation

|November 30, 2023

Summary

Emerging kidney transplant rejection phenotypes present diagnostic challenges. Novel tools are crucial for accurate diagnosis, staging, and grading of allograft rejection to improve patient outcomes.

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Last Updated: Jul 9, 2025

Mouse Kidney Transplantation: Models of Allograft Rejection

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection

A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection

Published on: February 2, 2022

Area of Science:

Nephrology
Transplant Immunology
Pathology

Background:

Allograft rejection remains a primary cause of kidney transplant failure despite advances in immunosuppression.
Prolonged graft survival reveals complex rejection phenotypes, including mixed cellular and antibody-mediated, and acute/chronic disease patterns.

Approach:

This review examines emerging rejection phenotypes based on time post-transplantation.
It highlights the diagnostic challenges posed by these complex presentations.
The role of novel ancillary diagnostic tools in improving biopsy-based rejection diagnosis is discussed.

Key Points:

Novel rejection phenotypes are increasingly observed with longer-term graft survival.
Accurate diagnosis is critical due to the complex and overlapping nature of rejection mechanisms.
Advanced diagnostic tools are essential for precise staging and grading.

Conclusions:

Prospective validation and clinical adoption of molecular and computational diagnostic tools are necessary.
These tools promise to enhance the accuracy of diagnosing, staging, and grading allograft rejection.
Improved diagnostic accuracy will ultimately support better patient management and graft survival.