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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

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Published on: October 14, 2016

Pediatric Odontogenic Tumors.

Yingci Liu¹, Molly Housley Smith², Paras B Patel^3,4

¹Rutgers School of Dental Medicine, Newark, NJ, USA.

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

|November 30, 2023

Summary

This review covers rare pediatric jaw tumors called odontogenic tumors. It details their clinical, radiographic, histopathologic, and molecular features, along with management strategies.

Keywords:

Odontogenic tumors ameloblastoma mouth neoplasms odontoma oral pathology pediatric stomatognathic diseases

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Area of Science:

Oral pathology
Pediatric oncology
Dental medicine

Background:

Odontogenic tumors are rare neoplasms originating from tooth-forming tissues.
Certain types exhibit a notable predilection for pediatric patients.

Purpose of the Study:

To review the clinical, radiographic, histopathologic, and molecular characteristics of odontogenic tumors in children.
To discuss current management approaches for these pediatric jaw tumors.

Main Methods:

Literature review of select odontogenic tumors with pediatric predilection.
Synthesis of data on clinical presentation, imaging findings, histopathology, and molecular features.
Review of established and emerging treatment strategies.

Main Results:

Identified key odontogenic tumors common in pediatric populations, including unicystic ameloblastoma and adenomatoid odontogenic tumor.
Detailed the distinct clinical, radiographic, and histopathologic profiles of these tumors.
Summarized molecular alterations relevant to diagnosis and potential targeted therapies.

Conclusions:

Understanding the specific characteristics of pediatric odontogenic tumors is crucial for accurate diagnosis.
Multidisciplinary management, integrating surgical and potentially molecular approaches, is essential for optimal outcomes in children.
Further research into the molecular underpinnings may enhance therapeutic strategies.