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Updated: Jul 9, 2025

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones

Irina Ihnatenko1,2, Marco J Müller1,2, Oliver C F Orban1,2

  • 1Institute of Medicinal and Pharmaceutical Chemistry, TU Braunschweig, Braunschweig, Germany.

Plos One
|November 30, 2023
PubMed

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