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Updated: Jul 9, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Link prediction and feature relevance in knowledge networks: A machine learning approach
Antonio Zinilli1, Giovanni Cerulli1
1IRCRES-Research Institute on Sustainable Economic Growth, CNR-National Research Council, Rome, Italy.
Abstract:
We propose a supervised machine learning approach to predict partnership formation between universities. We focus on successful joint R&D projects funded by the Horizon 2020 programme in three research domains: Social Sciences and Humanities, Physical and Engineering Sciences, and Life Sciences. We perform two related analyses: link formation prediction, and feature importance detection. In predicting link formation, we consider two settings: one including all features, both exogenous (pertaining to the node) and endogenous (pertaining to the network); and one including only exogenous features (thus removing the network attributes of the nodes). Using out-of-sample cross-validated accuracy, we obtain 91% prediction accuracy when both types of attributes are used, and around 67% when using only the exogenous ones. This proves that partnership predictive power is on average 24% larger for universities already incumbent in the programme than for newcomers (for which network attributes are clearly unknown). As for feature importance, by computing super-learner average partial effects and elasticities, we find that the endogenous attributes are the most relevant in affecting the probability to generate a link, and observe a largely negative elasticity of the link probability to feature changes, fairly uniform across attributes and domains.
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