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Updated: Jul 9, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Link prediction and feature relevance in knowledge networks: A machine learning approach
Antonio Zinilli1, Giovanni Cerulli1
1IRCRES-Research Institute on Sustainable Economic Growth, CNR-National Research Council, Rome, Italy.
We developed a machine learning model to predict university partnerships for joint R&D projects. Network features significantly improve prediction accuracy, highlighting the importance of existing collaborations for future ones.
Area of Science:
- Social Sciences
- Physical and Engineering Sciences
- Life Sciences
Background:
- University partnerships are crucial for successful joint research and development.
- The Horizon 2020 programme funds collaborative R&D projects across diverse scientific domains.
- Understanding factors influencing partnership formation is key to fostering innovation.
Purpose of the Study:
- To develop a supervised machine learning model for predicting university partnership formation.
- To analyze the impact of network (endogenous) and non-network (exogenous) features on collaboration prediction.
- To identify key features driving successful joint R&D project formation.
Main Methods:
- Supervised machine learning for link formation prediction.
- Feature importance analysis using super-learner partial effects and elasticities.
- Cross-validation accuracy assessment in two settings: with all features and with exogenous features only.
Main Results:
- Achieved 91% prediction accuracy when including both network and non-network features.
- Prediction accuracy dropped to 67% when using only non-network features.
- Existing program participants (incumbents) showed 24% higher predictive power than newcomers.
Conclusions:
- Network attributes (endogenous features) are most influential in predicting university partnerships.
- The probability of link formation decreases with feature changes, uniformly across attributes and domains.
- Existing collaborations significantly enhance the predictive power of partnership formation models.
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