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Three-year changes in sex judgment using color fundus parameters in elementary school students
Takehiro Yamashita1, Ryo Asaoka2,3,4,5, Hiroto Terasaki1
1Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima-shi, Kagoshima, Japan.
Plos One
|November 30, 2023
Summary
Sex differences in the eye
Area of Science:
- Ophthalmology
- Biometrics
- Pediatric eye research
Background:
- Previous research indicated sex determination is possible using color fundus photography (CFP).
- Limited understanding exists regarding how fundus parameter sex differences evolve throughout childhood.
Purpose of the Study:
- To investigate sex determination accuracy using fundus parameters in elementary school students.
- To analyze the longitudinal changes in sex-discriminating fundus parameters across childhood.
Main Methods:
- Prospective observational longitudinal study of 109 children's right eyes over 4 years (ages 8.5-11.5).
- Calculation of tessellation fundus index (TFI) and quantification of optic disc area, ovality ratio, papillomacular angle, and retinal vessel parameters.
- Sex prediction using 54 fundus parameters via L2 regularized binomial logistic regression.
Main Results:
- Analysis included 53 boys and 56 girls.
- Discrimination accuracy significantly increased with age, from 56.3% at 8.5 years to 73.1% at 11.5 years.
- The tessellation fundus index showed age-related changes in sex discrimination.
Conclusions:
- Sex determination accuracy using fundus photography parameters improves during childhood.
- Fundus parameters offer a potential method for non-invasive sex determination in pediatric populations.
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