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Induction of sperm abnormalities in mice by quercetin
Abstract:
Sperm abnormalities in mice induced by IP injection of quercetin at total cumulative doses of 16, 32, 80, and 160 mg/kg b. wt. administered fractionally on 5 successive days were quantitated by assessing the percent of sperm with abnormal heads or tails. Five weeks after the final injection a maximum of 14.8% abnormal sperm were observed with a total quercetin dose of 80 mg/kg b. wt. compared to the spontaneous control of 0.98%. Concomittantly, a 32.1% reduction in testicular weight occurred compared to control mice which was coincident with a reduction in sperm count of 28%.
Insights
Quercetin exposure in mice significantly increased sperm abnormalities, with a dose-dependent effect observed. High doses also led to reduced testicular weight and sperm count, indicating potential reproductive toxicity.
Area of Science:
- Toxicology
- Reproductive Biology
- Biochemistry
Background:
- Quercetin is a widely distributed flavonoid with potential health benefits.
- However, its effects on reproductive health require thorough investigation.
Purpose of the Study:
- To evaluate the impact of quercetin administration on sperm parameters and testicular function in mice.
Main Methods:
- Mice received fractional intraperitoneal injections of quercetin at cumulative doses (16, 32, 80, 160 mg/kg).
- Sperm abnormalities (head/tail) were quantified five weeks post-injection.
- Testicular weight and sperm count were assessed.
Main Results:
- A dose of 80 mg/kg quercetin resulted in 14.8% abnormal sperm, compared to 0.98% in controls.
- This dose also caused a 32.1% reduction in testicular weight and a 28% decrease in sperm count.
Conclusions:
- Quercetin exposure induces significant sperm abnormalities in mice.
- The findings suggest quercetin may possess reproductive toxicity, impacting testicular function and sperm production.
