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Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological decline
Edwin Mogere1, Davis Cheruiyot2, Manakhe Nassiuma1
1Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Nairobi, Kenya.
Abstract:
This case serves as a reminder of the infrequent, yet consequential occurrence of cerebellar degeneration linked to phenytoin usage. Whilst emphasizes the importance of monitoring patients on long-term phenytoin therapy, and it further suggests considering employing bedside imaging tools such as Ultrasound fusion imaging for follow-up of patients at risk of this type of disorder. We present a case study involving a 23-year-old woman who experienced significant neurological impairment resulting in severe cerebellar atrophy while undergoing phenytoin treatment. On cessation of phenytoin, the patient exhibited improvement with enhanced cerebellar function.
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