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A combined electrohydrodynamic atomization method for preparing nanofiber/microparticle hybrid medicines.

Liang Sun1, Jianfeng Zhou2, Yaoning Chen2

  • 1Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Frontiers in Bioengineering and Biotechnology
|November 30, 2023
PubMed
Summary

This study developed a novel hybrid material combining nanofibers and microparticles to treat bacterial prostatitis. The hybrid drug delivery system offers controlled release of both Western and traditional Chinese medicines, enhancing antibacterial efficacy.

Keywords:
coaxial electrosprayingelectrospinningmicro/nano hybridsprostatitissequential release

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Bacterial prostatitis treatment faces challenges with traditional drug delivery methods, leading to inefficient and inconvenient therapies.
  • Current approaches often involve multiple dosage forms and administration routes, compromising patient compliance and therapeutic outcomes.
  • There is a need for advanced drug delivery systems that ensure controlled and targeted release of therapeutic agents for prostatitis.

Purpose of the Study:

  • To develop a novel hybrid material integrating electrosprayed core-shell microparticles and electrospun nanofibers for enhanced bacterial prostatitis treatment.
  • To co-encapsulate Ningmitai (NMT), a traditional Chinese medicine, and ciprofloxacin (CIP), a Western medicine, for separately controlled release.
  • To evaluate the fabrication process, drug release profiles, and antibacterial efficacy of the developed hybrid system.

Main Methods:

  • A combined electrohydrodynamic atomization (EHDA) method, incorporating coaxial electrospraying and blending electrospinning, was employed in a single step.
  • Polyvinylpyrrolidone (PVP) and pH-sensitive Eudragit® S100 (ES100) were used as polymeric matrices for nanofibers and microparticles, respectively.
  • Characterization involved scanning electron microscopy (SEM), transmission electron microscopy (TEM), and drug release studies.

Main Results:

  • The EHDA hybrids successfully formed CIP-PVP nanofibers and NMT-ES100 core-shell microparticles.
  • Rapid release of ciprofloxacin (CIP) and sustained release of Ningmitai (NMT) were confirmed through in vitro studies.
  • The hybrid system demonstrated significantly enhanced antibacterial activity against *Escherichia coli dh5α* and *Bacillus subtilis Wb800* compared to individual components.

Conclusions:

  • The developed hybrid nanomedicine/micromicine system offers a promising approach for synergistic and convenient therapy in bacterial prostatitis.
  • The integration of electrospinning and electrospraying provides a straightforward fabrication method for advanced drug delivery systems.
  • Controlled sequential release of dual drugs within a single hybrid material enhances therapeutic potential and addresses limitations of traditional treatments.