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Introduction to Fibroblasts01:09

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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
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Updated: Jul 9, 2025

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Fibroblastic osteosarcoma: A perplexing entity.

Komal Preet Kaur1, Sanchita Kundu1, Arunit Chatterjee1

  • 1Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Science and Research, West Bengal, India.

Journal of Oral and Maxillofacial Pathology : JOMFP
|November 30, 2023
PubMed
Summary
This summary is machine-generated.

Osteosarcoma (OS) of the head and neck, particularly the jaw, presents unique diagnostic challenges. This case highlights how advanced diagnostic methods confirm OS variants, improving treatment opportunities and patient outcomes.

Keywords:
Fibroblastic variantSATB2mandibleosteosarcomapleomorphismspindle cellsstoriform streaming pattern

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Area of Science:

  • Oncology
  • Pathology
  • Radiology

Background:

  • Osteosarcoma (OS) is the most common primary malignant bone tumor, typically affecting long bones.
  • Head and neck OS, including jaw osteosarcoma, exhibit distinct biological and clinical characteristics compared to other sites.
  • Diagnostic challenges arise from the diverse radiological and histological presentations of jaw OS.

Observation:

  • A case of advanced osteosarcoma of the mandible in a 45-year-old woman presenting with swelling.
  • The patient's presentation required comprehensive diagnostic evaluation.

Findings:

  • Radiological, histopathological, and immunohistochemical analyses were crucial for confirming the OS variant.
  • Multimodality diagnostic approaches are essential for accurate diagnosis of challenging OS cases.

Implications:

  • Accurate diagnosis of jaw osteosarcoma through integrated methods improves treatment planning.
  • Enhanced diagnostic strategies offer better opportunities for cure and improved quality of life for patients with OS.