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Aspiration pneumonia caused by fibrous material in rats

K Yamasaki

    Jikken Dobutsu. Experimental Animals
    |October 1, 1986
    PubMed

    Insights

    Oral administration of carboxymethyl cellulose solution in rats led to aspiration pneumonia. Histological analysis revealed fibrous material and inflammation in the lungs, indicating a potential risk associated with this substance.

    Area of Science:

    • Toxicology
    • Pulmonary Pathology

    Background:

    • Carboxymethyl cellulose (CMC) is a common excipient.
    • Potential for aspiration of oral solutions exists.

    Purpose of the Study:

    • To investigate the occurrence and characteristics of aspiration pneumonia in rats following oral CMC administration.

    Main Methods:

    • Oral gavage of 0.5% carboxymethyl cellulose solution in Sprague-Dawley rats.
    • Gross and histological examination of lung tissue.

    Main Results:

    • Aspiration pneumonia was observed in 8 out of 60 rats.
    • Gross findings included white nodular foci in lung parenchyma.
    • Histology showed fibrous material, inflammatory cells, and granuloma formation.

    Conclusions:

    • Inhaled carboxymethyl cellulose fibers from the oral solution likely caused aspiration pneumonia.
    • This highlights a potential pulmonary risk associated with oral CMC administration.

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