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The associations between asthma and common comorbidities: a comprehensive Mendelian randomization study
Xuezhao Wang1,2, Yuchen Huang1,2, Xiaochen Li1,2
1Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Frontiers in Medicine
|November 30, 2023
Summary
This study found that asthma is bidirectionally linked with chronic sinusitis, atopic dermatitis, allergic conjunctivitis, and allergic rhinitis. Asthma also increases the risk for chronic obstructive pulmonary disease and allergic urticaria.
Area of Science:
- Genetics and Epidemiology
- Respiratory Medicine
- Immunology
Background:
- Asthma is a chronic respiratory condition frequently co-occurring with other diseases (comorbidities).
- The precise causal links between asthma and its common comorbidities remain largely undetermined.
- This research investigates the genetic associations between asthma and prevalent comorbidities.
Purpose of the Study:
- To determine the causal relationship between genetically predicted asthma and common comorbidities.
- To explore bidirectional associations, examining if comorbidities also influence asthma risk.
Main Methods:
- Searched PubMed and GWAS databases to identify 26 asthma comorbidities.
- Employed bidirectional Mendelian randomization across two independent Genome-Wide Association Studies (GWAS).
- Validated findings using multivariate Mendelian randomization and sensitivity analyses.
Main Results:
- Genetically predicted asthma showed significant associations with increased risk of chronic sinusitis, atopic dermatitis, allergic conjunctivitis, and allergic rhinitis.
- Asthma itself was significantly associated with increased risk for chronic obstructive pulmonary disease, chronic sinusitis, atopic dermatitis, allergic conjunctivitis, and allergic rhinitis.
- Hyperthyroidism showed a potential increased risk for asthma, while asthma potentially increased the risk for allergic urticaria.
Conclusions:
- Confirmed significant bidirectional causal links between asthma and chronic sinusitis, atopic dermatitis, allergic conjunctivitis, and allergic rhinitis.
- Identified hyperthyroidism as a potential risk factor for asthma.
- Established that asthma elevates the risk for chronic obstructive pulmonary disease and allergic urticaria.
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