Chronic ethanol consumption and aging: changes in lipid composition of liver microsomes

Both aging and chronic ethanol consumption have been found to produce changes in lipid composition. Severity of intoxication, withdrawal and release of gamma-aminobutyric acid following chronic ethanol consumption have been shown to be associated with age. It was predicted in this study that aged mice would differ in response to ethanol-induced changes in lipid composition of liver microsomes as compared to younger mice. Two different age groups of C57BL/6NNIA male mice (6 and 28 months) were administered an ethanol or control liquid diet for 24 days. Liver microsomes were prepared on Day 25. Age and ethanol consumption significantly affected liver weight and the ratio of liver weight to body weight. PC significantly decreased and PE significantly increased in both the young and old ethanol groups. Cholesterol and total phospholipid content were not affected by age or chronic ethanol consumption. Aged animals were able to adapt to the effects of chronic ethanol administration to the same extent as younger animals. These findings differ from studies that have examined effects of chronic ethanol consumption on behavior and neurotransmitter release among different age groups of mice. While the results are specific for liver microsomes, it appears that chronic ethanol consumption has less of an effect on liver function as compared to brain function in aged mice.