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Immunomodulatory roles of metalloproteinases in rheumatoid arthritis

Yanqin Bian1,2, Zheng Xiang1,2, Yaofeng Wang1,2

  • 1Institute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.

Frontiers in Pharmacology
|November 30, 2023
PubMed

Insights

Matrix metalloproteinases (MMPs) are crucial in rheumatoid arthritis (RA) pathogenesis, driving inflammation and bone destruction. Targeting MMPs shows promise for RA treatment and personalized medicine strategies.

Area of Science:

  • Biochemistry
  • Immunology
  • Rheumatology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease causing joint inflammation and bone damage.
  • Matrix metalloproteinases (MMPs) are enzymes involved in extracellular matrix (ECM) degradation and remodeling.
  • MMPs play roles in cell proliferation, migration, inflammation, and metabolism, with growing interest in their function in immune diseases.

Purpose of the Study:

  • To review the regulation and expression of MMPs in RA.
  • To discuss the role of MMPs in RA pathogenesis, including ECM remodeling, angiogenesis, oxidative stress, cell migration, cytokine production, PANoptosis, and bone destruction.
  • To summarize clinical trials targeting MMPs in inflammatory diseases and explore their therapeutic potential in RA.

Main Methods:

  • Literature review of MMPs' role in rheumatoid arthritis.
  • Analysis of MMP expression and regulation in RA.
  • Summary of clinical trials and therapeutic strategies involving MMP inhibition.

Main Results:

  • MMPs are significantly involved in various pathological processes in RA.
  • MMP inhibition is being investigated as a therapeutic strategy for RA.
  • MMPs show potential as biomarkers for treatment response and disease stratification.

Conclusions:

  • MMPs are key players in RA pathogenesis and progression.
  • Targeting MMPs offers a promising avenue for RA treatment.
  • MMPs can serve as valuable biomarkers for personalized medicine in RA management.
Keywords:
angiogenesisbone destructionmatrix metalloproteinasesrheumatoid arthritistarget

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