Geriatric Assessment in Acute Myeloid Leukemia
Justin D Woods1, Heidi D Klepin1
1Section on Hematology and Oncology, Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston Salem, North Carolina, USA.
Acta Haematologica
|November 30, 2023
Summary
Geriatric assessment (GA) helps tailor acute myeloid leukemia (AML) treatments for older adults. GA identifies fitness for therapy, improving outcomes and avoiding over- or under-treatment in AML patients.
Area of Science:
- Hematology
- Geriatrics
- Oncology
Background:
- Acute myeloid leukemia (AML) predominantly affects older adults with diverse health statuses.
- Current treatment strategies for AML in older adults vary, yet outcomes remain suboptimal due to disease biology and treatment tolerance.
- Relying solely on chronological age for AML treatment decisions risks inappropriate care.
Purpose of the Study:
- To review the evidence supporting the use of geriatric assessment (GA) in older adults with AML.
- To discuss the implications of GA for clinical practice and future research in AML management.
Main Methods:
- Geriatric assessment (GA) involves validated tools evaluating physical function, comorbidities, cognition, nutrition, psychological health, and social support.
- Review of existing literature on the feasibility and impact of GA in older adults undergoing AML therapy.
Main Results:
- Performing GA in older adults starting AML therapy is feasible.
- GA measures, particularly those assessing physical function, cognition, and mood, correlate with mortality and toxicity in AML patients.
- GA can help optimize treatment decisions and clinical trial design for older AML patients.
Conclusions:
- Geriatric assessment is a valuable tool for evaluating fitness in older adults with AML.
- Integrating GA into clinical practice can improve treatment individualization and patient outcomes in AML.
- Further research is needed to fully leverage GA for enhancing AML treatment strategies.
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