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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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Ophthalmic diseases in meningitis within the pediatric population

Jia Yue You1, Milad Modabber2, Massimo Di Iorio3

  • 1Departments of Ophthalmology and Pediatric Surgery, Montreal Children's Hospital, McGill University, Montreal, QC.

Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
|November 30, 2023
PubMed

Insights

Meningitis can cause lasting vision problems in children, with over two-thirds experiencing ocular abnormalities. Increased awareness among healthcare providers is crucial for early detection and management of these pediatric ophthalmic complications.

Area of Science:

  • Ophthalmology
  • Pediatrics
  • Neurology

Background:

  • Meningitis is a serious infection that can affect children.
  • Ophthalmic complications following meningitis are not well-studied in developed countries.
  • Tertiary pediatric hospitals manage severe pediatric cases, including those with meningitis.

Purpose of the Study:

  • To investigate the spectrum of ocular and neuro-ophthalmic sequelae in pediatric patients diagnosed with meningitis.
  • To determine the frequency of ophthalmic abnormalities in children with meningitis presenting to a tertiary care center.
  • To raise awareness among healthcare providers about potential long-term visual complications of meningitis in children.

Main Methods:

  • Retrospective chart review of pediatric patients diagnosed with meningitis between 2006 and 2015.
  • Inclusion criteria focused on patients who received an ophthalmology consultation.
  • Analysis of demographic data, medical history, ocular findings, and imaging results to calculate the proportion of ocular abnormalities.

Main Results:

  • 8.4% of meningitis patients (72/861) received an ophthalmology consultation.
  • Of the 46 eligible patients, 67.4% (31/46) exhibited ocular abnormalities.
  • Commonly affected areas included visual acuity, extraocular movements, optic nerve function, pupillary reactivity, and periorbital/orbital cellulitis. Older children were more prone to findings.

Conclusions:

  • Meningitis frequently leads to ocular abnormalities in children treated at a tertiary care center.
  • These ophthalmic complications can be persistent, impacting long-term visual health.
  • Ophthalmologists and healthcare providers should maintain a high index of suspicion for ocular issues in pediatric meningitis patients.
Abstract

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