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Updated: Jul 9, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
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An Overview of the Mechanism behind Excessive Volume of Pericardial Fat in Heart Failure

Sandeep Karna1, Ki-Woon Kang1

  • 1Division of Cardiology, Cardiovascular Arrhythmia Center, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.

Journal of Obesity & Metabolic Syndrome
|November 30, 2023
PubMed

Insights

Pericardial fat (PCF) contributes to heart failure (HF) through various mechanisms like inflammation and oxidative stress. Understanding these PCF-related pathways is crucial for developing new HF treatments.

Area of Science:

  • Cardiology
  • Endocrinology
  • Molecular Biology

Background:

  • Heart failure (HF) is a complex syndrome driven by myocardial dysfunction.
  • Pericardial fat (PCF) is increasingly recognized for its role in cardiovascular disease.
  • Increased PCF volume is a known risk factor for HF development.

Purpose of the Study:

  • To review the multifaceted mechanisms by which pericardial fat influences heart failure.
  • To elucidate the neuroendocrine functions of PCF in relation to myocardial performance.
  • To summarize the contribution of PCF-derived factors to HF pathogenesis.

Main Methods:

  • Literature review of studies investigating pericardial fat and heart failure.
  • Analysis of mechanisms including adipokine secretion, inflammation, and oxidative stress.
  • Synthesis of data on stem cell proliferation and autonomic dysregulation linked to PCF.

Main Results:

  • PCF acts as active neuroendocrine tissue influencing myocardial function.
  • Mechanisms include adipokine hypersecretion, proinflammatory cytokine release, and oxidative stress.
  • Stem cell proliferation and autonomic nervous system dysregulation in PCF also contribute to HF.

Conclusions:

  • Pericardial fat plays a significant role in the development and progression of heart failure.
  • Targeting PCF-mediated pathways offers potential therapeutic strategies for HF.
  • Further research into PCF's role can advance understanding of cardiovascular disease.

Keywords:
FatHeart diseaseHeart failure

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