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Relationship between klotho and physical function in healthy aging.

Eliott Arroyo1,2, Cecilia A Leber1,3, Heather N Burney4

  • 1Division of Nephrology & Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

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|November 30, 2023
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Summary
This summary is machine-generated.

Serum Klotho levels decrease with age, even in healthy adults, potentially impacting physical function before noticeable decline. This study in healthy adults shows Klotho decline starts in middle age.

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Area of Science:

  • Gerontology
  • Biochemistry
  • Exercise Physiology

Background:

  • Epidemiological studies link circulating Klotho to physical function, primarily in older adults with comorbidities.
  • Previous research has not focused on the relationship between Klotho and physical function in healthy, community-dwelling adults across different age groups.

Purpose of the Study:

  • To investigate the association between serum Klotho levels and physical function in a cohort of healthy adults.
  • To determine if Klotho levels differ across various age groups and correlate with specific physical performance measures.

Main Methods:

  • Cross-sectional study involving 80 healthy adults aged 20-85 years.
  • Serum Klotho levels were measured and analyzed across four age groups (20-34, 35-49, 50-64, ≥65 years).
  • Physical function was assessed using grip strength, chair stand tests, and the 6-minute walk test (6MWT).

Main Results:

  • Serum Klotho levels were significantly lower in the 50-64 and ≥65 years age groups compared to the 20-34 years group.
  • No significant difference in Klotho levels was found between low and high physical performers.
  • The ≥65 years group exhibited a shorter 6MWT distance compared to the 20-34 years group.
  • Klotho levels correlated negatively with age and body fat percentage, and positively with 6MWT distance.

Conclusions:

  • Circulating Klotho levels decline with age, beginning as early as the fifth decade in healthy adults.
  • This decline may precede observable age-related impairments in exercise capacity.
  • Klotho's association with age and physical function warrants further investigation in younger and middle-aged populations.