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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Related Experiment Video

Updated: Jul 9, 2025

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
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Therapeutic Fusion Proteins.

Morgan C Marsh1, Shawn C Owen2,3,4

  • 1Department of Molecular Pharmaceutics, University of Utah, 30 South 2000 East, Room 301, Salt Lake City, Utah, 84112, USA.

The AAPS Journal
|November 30, 2023
PubMed
Summary

Therapeutic fusion proteins combine biomolecules for enhanced disease treatment. These versatile constructs offer increased half-life, targeted delivery, and sustained signaling, paving the way for diverse biopharmaceutical applications.

Keywords:
biologicsfusion proteinstherapeutic proteins

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Area of Science:

  • Biotechnology and Pharmaceutical Sciences
  • Molecular Biology and Engineering

Background:

  • Therapeutic fusion proteins are hybrid biomolecular constructs designed to combine distinct functionalities into a single therapeutic agent.
  • Their development leverages advances in protein engineering and antibody technologies to create novel treatment modalities.
  • Established applications include half-life extension, enhancing drug exposure and efficacy, with numerous clinical successes.

Purpose of the Study:

  • To explore the diverse applications and potential of therapeutic fusion proteins in disease treatment.
  • To highlight the design principles and functional capabilities of these engineered biomolecules.
  • To underscore the expanding scope of fusion proteins beyond oncology into various therapeutic areas.

Main Methods:

  • Engineering of hybrid constructs by fusing distinct biomolecules, such as proteins and antibody derivatives.
  • Design of fusion proteins to achieve specific therapeutic functions like increased half-life, targeted delivery, and sustained signaling.
  • Leveraging existing successes in cancer therapy to explore applications in other diseases.

Main Results:

  • Fusion proteins can be designed with additive effects from combined biomolecules, localizing therapeutic mechanisms.
  • Half-life extension is a well-established function with significant clinical validation.
  • Emerging designs incorporate dual active functions and targeting domains for advanced therapeutic strategies.

Conclusions:

  • Therapeutic fusion proteins offer a versatile platform for developing novel treatments across a spectrum of diseases.
  • Continued research and development in biopharmaceuticals will drive innovation in fusion protein design and application.
  • The adaptability of fusion proteins positions them as a key area for future therapeutic advancements.