Cyclodextrin-based nanosponges as promising carriers for active pharmaceutical ingredient

Area of Science:

• Nanotechnology
• Materials Science
• Pharmaceutical Sciences

Background:

• Effective drug distribution to target sites remains a significant challenge in pharmaceutical research.
• Nanotechnology offers innovative solutions, with nanosponges emerging as key players in drug delivery systems.

Purpose of the Study:

• To provide a comprehensive review of nanosponges for drug delivery.
• To discuss the utilization, benefits, production, materials, and characterization of nanosponges.

Main Methods:

• Review of existing literature on nanosponge technology.
• Analysis of nanosponge structure, properties, and fabrication methods.
• Exploration of diverse applications in pharmaceutical formulations.

Main Results:

• Nanosponges are hyper-crosslinked polymer-based colloidal structures with porous nanoparticles capable of encapsulating active pharmaceutical ingredients.
• They facilitate controlled and targeted drug release, improving therapeutic efficacy.
• Nanosponges can be formulated into various dosage forms, including oral, parenteral, topical, and inhalation.

Conclusions:

• Nanosponges represent a significant advancement in drug delivery systems.
• Their unique properties offer a promising platform for developing effective and targeted pharmaceutical formulations.
• Further research into nanosponge technology can unlock new therapeutic possibilities.