Related Experiment Video
Updated: Jul 9, 2025

In Vitro Disassembly of Influenza A Virus Capsids by Gradient Centrifugation
Published on: March 27, 2016
The ER-Golgi transport of influenza virus through NS1-Sec13 association during virus replication
Sonja C J H Chua1,2,3,4,5, Jianzhou Cui1,2,3, Karishma Sachaphibulkij1,2,3
1Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore , Singapore, Singapore.
Importance:
Influenza A virus is a respiratory virus that can cause complications such as acute bronchitis and secondary bacterial pneumonia. Drug therapies and vaccines are available against influenza, albeit limited by drug resistance and the non-universal vaccine administration. Hence there is a need for host-targeted therapies against influenza to provide an effective alternative therapeutic target. Sec13 was identified as a novel host interactor of influenza. Endoplasmic reticulum-to-Golgi transport is an important pathway of influenza virus replication and viral export. Specifically, Sec13 has a functional role in influenza replication and virulence.
More Related Videos
Related Concept Videos
Leaky Scanning
Intralumenal Vesicles and Multivesicular Bodies
Coat Assembly and GTPases
Coat assembly depends on the local availability of phosphatidylinositol phosphates or PIPs and GTP-binding proteins. Adaptor proteins, which link the coat proteins to the membrane, bind to these PIPs and play a crucial role in controlling...
Vesicular Tubular Clusters
With the help of motor proteins such...
Intracellular Movement of Viruses and Bacteria
Export of Misfolded Proteins out of the ER

