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Updated: Jul 9, 2025
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Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
Published on: June 16, 2011
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RNA virus diversity in rodents.
Yayu Fan1, Yutong Hou1, Qian Li1
1Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650500, People's Republic of China.
Archives of Microbiology
|December 1, 2023
Summary
Rodents harbor diverse RNA viruses with potential to cause zoonotic diseases. This study analyzes rodent RNA virus data to understand diversity and risks of human infectious disease outbreaks.
Area of Science:
- Virology
- Public Health
- Epidemiology
Background:
- Zoonotic disease emergencies often involve RNA viruses in rodents, posing significant public health risks.
- Advances in meta-genomics have increased the discovery of novel rodent viruses, highlighting their role as reservoirs for zoonotic pathogens.
- Limited knowledge exists regarding rodent RNA viral diversity and factors driving zoonotic spillover events.
Purpose of the Study:
- To analyze the diversity and composition of rodent RNA viruses.
- To review human infectious diseases caused by rodent RNA viruses.
- To discuss challenges in understanding rodent-borne zoonotic disease risks.
Main Methods:
- Utilized virus records from the Database of Rodent-associated Viruses (DRodVir/ZOVER).
- Included data from published literature and GenBank.
- Systematically reviewed rodent RNA virus-induced human infectious diseases.
Main Results:
- Identified a growing number of novel viruses discovered in rodents.
- Highlighted rodents as critical reservoirs for zoonotic viruses.
- Acknowledged the substantial impact of these viruses on public health.
Conclusions:
- Rodents are significant reservoirs for RNA viruses with zoonotic potential.
- Further research is needed to understand rodent viral diversity and mitigate spillover risks.
- Addressing knowledge gaps is crucial for preventing future zoonotic epidemic outbreaks.
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