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Related Concept Videos

Protein Families02:47

Protein Families

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Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
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The Proteasome02:18

The Proteasome

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Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
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Protein-protein Interfaces02:04

Protein-protein Interfaces

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Related Experiment Video

Updated: Jul 9, 2025

Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
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Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics

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Web-Based Resources to Investigate Protease Function.

Salvatore Santamaria1

  • 1Department of Biochemical Sciences, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK. s.santamaria@surrey.ac.uk.

Methods in Molecular Biology (Clifton, N.J.)
|December 1, 2023
PubMed
Summary
This summary is machine-generated.

The human genome

Keywords:
ADAMTSCancerDatabaseMetalloproteaseProteases

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Area of Science:

  • Biological Sciences
  • Bioinformatics
  • Genomics

Background:

  • The advent of Big Data in biological sciences began with the 2001 human genome draft.
  • Biological datasets have grown exponentially in complexity and volume.
  • Public repositories are crucial for managing and disseminating research data.

Purpose of the Study:

  • To provide a list of resources for investigating protease function.
  • To highlight the importance of data sharing in biological research.

Main Methods:

  • Review of public biological data repositories.
  • Identification of resources relevant to protease function.
  • Discussion of the impact of Big Data and AI on biological research.

Main Results:

  • The Protein Data Bank now exceeds 200,000 entries.
  • AI advancements like AlphaFold rely on publicly available data.
  • A curated list of resources for protease function research is presented.

Conclusions:

  • Public data repositories are essential for advancing biological research.
  • The collective effort in data sharing enables significant scientific breakthroughs.
  • Investigating protease function can be facilitated by utilizing available resources.