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Related Experiment Video

Updated: Jul 9, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Rodent genetically modified models of glaucoma.

Yunhua Loo¹, Anita Sook Yee Chan¹, Chiea Chuen Khor²

¹Duke-NUS Medical School, Singapore; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

Molecular Aspects of Medicine

|December 1, 2023

Summary

Genetic models are crucial for understanding glaucoma, a leading cause of blindness. Studying these models helps reveal disease mechanisms and test new therapies for various glaucoma types.

Keywords:

Animal models Genetically modified mice Normal tension glaucoma Pigmentary glaucoma Primary angle closure glaucoma Primary open angle glaucoma

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Last Updated: Jul 9, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

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Published on: February 15, 2022

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Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Area of Science:

Ophthalmology
Genetics
Animal Models

Background:

Glaucoma is a major cause of irreversible blindness with a significant heritable component.
Genome-wide association studies have identified numerous genetic risk loci for glaucoma.
Understanding the genetic basis of glaucoma is key to developing effective treatments.

Purpose of the Study:

To review genetic models used for studying major forms of human glaucoma.
To highlight how these models advance glaucoma pathogenesis research.
To discuss the utility of genetic models in pre-clinical therapy testing.

Main Methods:

Review of genetic models for primary open-angle glaucoma, normal-tension glaucoma, primary angle-closure glaucoma, pigmentary glaucoma, pseudoexfoliation glaucoma, and early-onset glaucomas.
Analysis of genotype-phenotype correlations in established glaucoma models.
Evaluation of the role of animal models in understanding glaucoma genetics.

Main Results:

Genetic models provide insights into the pathogenesis of various glaucoma subtypes.
These models are essential for characterizing genetic risk loci, particularly those in coding regions.
Animal models serve as valuable platforms for pre-clinical evaluation of potential glaucoma therapies.

Conclusions:

Genetic models are indispensable tools for unraveling the complex genetic architecture of glaucoma.
Studying these models significantly enhances our comprehension of human glaucoma.
Genetic models facilitate the development and testing of novel therapeutic strategies for glaucoma.