Related Experiment Video
Updated: Jul 9, 2025
Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research
Published on: April 21, 2023
Changes in myelinated nerve fibers induced by pulsed electrical stimulation: A microstructural perspective on the
Hongwei Zhao1, Yiqiang Li1, Yibo Zhang1
1Key Laboratory of CNC Equipment Reliability, Ministry of Education, Jilin University, Changchun, 130025, PR China; School of Mechanical & Aerospace Engineering, Jilin University, Changchun, 130025, PR China; Institute of Structured and Architected Materials, Liaoning Academy of Materials, Shenyang, 110167, PR China; Chongqing Research Institute of Jilin University, Chongqing, 401120, PR China.
Abstract:
Electrical brain stimulation technology is widely used in the clinic to treat brain neurological disorders. However, during treatment, patients may experience side effects such as pain, poor limb coordination, and skin rash. Previous reports have focused on the brilliant chapter on electrical brain stimulation technology and have not paid attention to patients' suffering caused by side effects during treatment. In this study, electrodes were arranged on the medulla oblongata. Pulsed electric fields of different frequencies were used to perform electrical stimulation to study the impact of electric fields on myelinated nerve fibers and reveal the possible microstructural origin of side effects. Transmission electron microscopy was used to analyze and quantify the changes in microstructure. The results illustrated that myelinated nerve fibers underwent atrophy under pulsed electric fields, with the mildest degree of atrophy under high-frequency (400 Hz) electric fields. Myelin sheaths experienced plate separation under pulsed electric fields, and a distinct laminar structure appeared. The microstructure changes may be related to the side effects of clinical electrical stimulation. This study can provide pathological possibilities for exploring the causes of the side effects of electrical stimulation and supply guidance for selecting electrical parameters for clinical electrical stimulation therapy from a distinctive perspective.
