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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Source And Potency Of Stem Cells01:27

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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Updated: Jul 9, 2025

Isolating Stem Cells from Soft Musculoskeletal Tissues
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Eyes open on stem cells.

Anna Altshuler1, Aya Amitai-Lange1, Waseem Nasser1

  • 1Department of Genetics & Developmental Biology, The Rappaport Faculty of Medicine & Research Institute, Technion Integrated Cancer Center, Technion - Israel Institute of Technology, Haifa 31096, Israel.

Stem Cell Reports
|December 1, 2023
PubMed
Summary
This summary is machine-generated.

The murine cornea is a powerful stem cell (SC) model for studying SC biology and regenerative medicine. Research reveals novel SC properties, differentiation flexibility, and the critical role of the SC niche in tissue repair and therapy.

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Area of Science:

  • Ophthalmology
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • The cornea has historically been a key model for stem cell (SC) research and regenerative medicine.
  • Seminal discoveries include early corneal transplantation and limbal SC identification for vision restoration.

Purpose of the Study:

  • To discuss the murine cornea as a robust stem cell (SC) model.
  • To highlight recent findings on SC properties, differentiation plasticity, and niche interactions.
  • To explore the broader relevance of the limbal SC model for other tissues, diseases, and therapies.

Main Methods:

  • Utilizing the murine cornea for individual stem cell (SC) tracing in vivo.
  • Reviewing recent experimental findings on SC behavior and niche interactions.

Main Results:

  • The murine cornea model allows for detailed SC tracing in living animals.
  • Recent studies reveal unexpected SC properties and progenitor cell plasticity.
  • The stem cell niche plays a crucial role in corneal regeneration.

Conclusions:

  • The limbal stem cell model offers significant insights into SC biology and regenerative medicine.
  • Understanding SCs and their niches has broad implications for treating various diseases and developing new therapies.