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Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
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Correspondence: The African snakebite Alliance.

George O Oluoch1, Ymkje Stienstra2, Janna M Schurer3

  • 1Kenya Snakebite Research & Intervention Centre, Kenya Institute of Primate Research, Ministry of Health, Karen, Nairobi, Kenya; Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

Toxicon : Official Journal of the International Society on Toxinology
|December 1, 2023
PubMed
Summary

Reducing the burden of snakebite envenoming requires addressing critical evidence gaps. The African Snakebite Alliance aims to generate research for better policy and practice.

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Area of Science:

  • Public Health
  • Clinical Medicine
  • Epidemiology

Background:

  • Snakebite envenoming poses a significant global health challenge, particularly in resource-limited settings.
  • Existing clinical care and public health strategies are hampered by substantial evidence gaps.
  • Bibliometric analysis reveals a lack of robust research networks contributing to these knowledge deficits.

Discussion:

  • The African Snakebite Alliance, a multidisciplinary initiative, is established to confront these challenges.
  • The alliance focuses on key research themes to generate essential evidence.
  • This evidence is crucial for informing and improving snakebite envenoming policies and clinical practices.

Key Insights:

  • Significant evidence gaps impede effective snakebite envenoming management and prevention.
  • Bibliometrics highlight the need for enhanced research collaboration and networking.
  • A structured, multidisciplinary approach is vital for advancing snakebite envenoming research.

Outlook:

  • The African Snakebite Alliance seeks to foster a collaborative research environment.
  • Generating high-quality evidence will guide evidence-based policy and practice improvements.
  • The ultimate goal is to reduce the global burden of snakebite envenoming.