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Updated: Jul 9, 2025

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
Published on: December 16, 2022
The ups and downs of bone-marrow adipose tissue in space
Guy Trudel1, Gerd Melkus2, Tammy Liu3
1Bone and Joint Research Laboratory, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada; Department of Medicine, Division of Physiatry, The Ottawa Hospital, Room 2505G, 505 Smyth Road, Ottawa, Ontario K1H 8M2, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Room 1321, Ottawa, Ontario K1H 8M5, Canada.
Abstract:
Knowledge is rapidly accumulating on basic roles and modulation of bone-marrow adipose tissue (BMAT). Among key modulators are physical forces on bones as exerted by gravity and exercise. Studying humans returning from space has revealed that, in addition to physical forces, local energetics within the bone marrow can play modulatory roles.

