Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.2K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.2K
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

1.9K
Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
1.9K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

1.8K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
1.8K
Whole Body Regeneration01:33

Whole Body Regeneration

3.4K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
3.4K
iPS Cell Differentiation01:22

iPS Cell Differentiation

2.7K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.7K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan.

EMBO molecular medicine·2025
Same author

Comprehensive evaluation of lifespan-extending molecules in C. elegans.

Aging cell·2025
Same author

Lifetime age-related changes in clinical laboratory results, aging clocks and mortality predictors in 2412 Golden Retrievers.

Aging cell·2025
Same author

Loss of H3K9 trimethylation leads to premature aging.

Research square·2025
Same author

Association between prescription drugs and all-cause mortality risk in the UK population.

Aging cell·2024
Same author

Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21.

Nature communications·2024
Same journal

A Non-Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver.

Aging cell·2026
Same journal

EGR1 Mediates Ursodeoxycholic Acid-Promoted Mitophagy to Prevent Postovulatory Aging of Porcine Oocytes.

Aging cell·2026
Same journal

Interplay of the ENS and Microbiota With Murine Gut Epithelium-Derived Organoids in Aging.

Aging cell·2026
Same journal

Age-Associated Senescence of Decidual Macrophages: A Key Mediator of Adverse Pregnancy Outcomes in Advanced Maternal Age.

Aging cell·2026
Same journal

Correction to "Telomerase Knockout in Myeloid Cells Predisposes Mice to Foam Cell Formation, Dyslipidemia, Lung Fibrosis, and Cardiac Dysfunction".

Aging cell·2026
Same journal

Bidirectional Relationship and Shared Mechanisms Between Sarcopenia and Osteoporosis: An Observational Study Integrating Genomic, Proteomic, and Metabolomic Data.

Aging cell·2026
See all related articles

Related Experiment Video

Updated: Jul 9, 2025

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle
09:14

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

Published on: October 26, 2017

9.6K

Partial cellular reprogramming: A deep dive into an emerging rejuvenation technology.

Patrick T Paine1,2, Ada Nguyen3, Alejandro Ocampo1,4

  • 1Department of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Vaud, Switzerland.

Aging Cell
|December 1, 2023
PubMed
Summary
This summary is machine-generated.

Partial cellular reprogramming offers a novel strategy to combat aging and age-associated diseases by rejuvenating cells without altering their identity. This approach holds significant therapeutic potential for age-related conditions.

Keywords:
agingaging hallmarkslifespanpartial cellular reprogrammingrejuvenation

More Related Videos

Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts
09:07

Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts

Published on: February 5, 2018

10.4K
Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method
10:52

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

Published on: January 19, 2020

10.4K

Related Experiment Videos

Last Updated: Jul 9, 2025

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle
09:14

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

Published on: October 26, 2017

9.6K
Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts
09:07

Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts

Published on: February 5, 2018

10.4K
Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method
10:52

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

Published on: January 19, 2020

10.4K

Area of Science:

  • Gerontology and regenerative medicine
  • Cell biology and epigenetics

Background:

  • Aging and age-associated diseases represent a significant global health challenge.
  • Cellular reprogramming offers a biological mechanism to influence cell fate and age.
  • Partial cellular reprogramming aims to achieve rejuvenation without dedifferentiation.

Purpose of the Study:

  • To explore the benefits of partial cellular reprogramming for aging.
  • To examine the limitations of current partial cellular reprogramming strategies.
  • To discuss future directions for therapeutic applications of cellular reprogramming in aging.

Main Methods:

  • Review of existing literature on cellular reprogramming and aging.
  • Analysis of studies investigating partial cellular reprogramming techniques.
  • Exploration of the molecular mechanisms underlying cellular age reversal.

Main Results:

  • Partial cellular reprogramming demonstrates potential for reversing cellular age markers.
  • Strategies exist to harness rejuvenation benefits while preserving cell identity.
  • Challenges remain in translating these findings to clinical applications.

Conclusions:

  • Partial cellular reprogramming is a promising therapeutic avenue for age-related diseases.
  • Further research is needed to overcome limitations and optimize safety.
  • This field presents significant translational and commercial opportunities.