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Infantile epileptic spasms syndrome: a cohort study of 88 children
Li-Hong Ren1, Jing Zhang1, Si-Xiu Li1
1Department of Pediatric Neurology, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, No. 1617, Riyue Aveneue, Chengdu, 611731, China.
Insights
Gender and metabolic abnormalities are key risk factors for non-etiology-specific infantile spasms (IS). Etiology also impacts symptom relief after treatment for IS.
Area of Science:
- Pediatric Neurology
- Clinical Research
- Medical Diagnostics
Background:
- Infantile spasms (IS) present diagnostic and treatment challenges.
- Understanding risk factors for non-etiology-specific IS is crucial.
- Identifying predictors of treatment response is essential for improved outcomes.
Purpose of the Study:
- To investigate risk factors for non-etiology-specific infantile spasms (IS).
- To analyze factors associated with unrelieved clinical symptoms after IS treatment.
Main Methods:
- Retrospective analysis of 88 children with IS (March 2018-December 2021).
- Patients categorized into etiology-specific vs. non-etiology-specific groups.
- Patients also grouped by remission vs. nonremission status post-treatment.
- Logistic regression analysis identified risk factors for non-etiology-specific IS.
Main Results:
- Significant differences between etiology-specific and non-etiology-specific groups included gender, family history, birth status, and metabolic abnormalities.
- Gender and metabolic abnormalities identified as risk factors for non-etiology-specific IS.
- Differences between remission and nonremission groups included family history, birth status, metabolic abnormalities, and brain MRI findings.
- Etiology emerged as a significant risk factor for unrelieved IS symptoms post-treatment.
Conclusions:
- Childhood infantile spasms without a clear etiology are linked to gender and metabolic abnormalities.
- The underlying etiology of IS is a critical factor influencing symptom persistence after treatment.
Background:
This study aimed to investigate and analyze the risk factors for non-etiology-specific infantile spasms (IS) and unrelieved clinical symptoms after treatment.
Methods:
Eighty-eight children with IS who were treated at our hospital from March 2018 to December 2021 were included in the study. The children were divided into etiology-specific (n = 46) and nonetiology-specific (n = 42) groups, based on the diagnostic results, and remission (n = 45) and nonremission (n = 43) groups, based on clinical outcomes after treatment. The clinical data from patients in the etiology-specific and nonetiology-specific groups and the remission and nonremission groups were compared. Risk factors for non-etiology-specific IS were identified using logistic regression analysis.
Results:
Gender, family history, birth status, and metabolic abnormalities were significantly different between the etiology-specific and non-etiology-specific groups. Gender and metabolic abnormalities were risk factors for nonetiology-specific IS. Family history, birth status, metabolic abnormalities, and brain magnetic resonance imaging were significantly different between the remission and nonremission groups, and different etiologies were risk factors for unrelieved symptoms after treatment.
Conclusion:
The occurrence of nonetiology-specific IS is associated with gender and metabolic abnormalities in children. After medication, unrelieved IS symptoms are associated with etiologies.
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