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Updated: Jul 9, 2025

Preparation of Single-Cell Suspension of Mouse Thymic Epithelial Cells and Staining of Intracellular Molecules for Flow Cytometric AnalysisMechanisms
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ACC1-mediated fatty acid biosynthesis intrinsically controls thymic iNKT cell development

Toshio Kanno1, Keisuke Miyako1,2, Takeru Endo1

  • 1Department of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute, 2-6-7 Kazusa Kamatari, Kisarazu, Chiba 292-0818, Japan.

International Immunology
|December 2, 2023
PubMed
Summary

Acetyl-CoA carboxylase 1 (ACC1) is crucial for invariant natural killer T (iNKT) cell development in the thymus. ACC1 controls iNKT cell survival, impacting their maturation and subset differentiation.

Keywords:
apoptosisfatty acid metabolism

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