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Apolipoproteins L1 and L3 control mitochondrial membrane dynamics

Laurence Lecordier1, Paul Heo2, Jonas H Graversen3

  • 1Laboratory of Molecular Parasitology, IBMM, Université Libre de Bruxelles, 6041 Gosselies, Belgium.

Cell Reports
|December 2, 2023
PubMed
Summary

Apolipoproteins L1 and L3 regulate mitochondrial dynamics. APOL3 controls phosphatidylinositol 4-kinase-IIIB (PI4KB) and vesicle-associated membrane protein-8 (VAMP8) interactions, impacting mitochondrial fission and fusion.

Keywords:
APOL1 risk variantsCOVANCOVID-19-associated nephropathyCP: Cell biologyHIV-associated nephropathyHIVANinflammationinterferon 1kidney diseasemitochondrion fission/fusionmitophagy

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