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Updated: Jul 9, 2025
Three-dimensional Biomimetic Technology: Novel Biorubber Creates Defined Micro- and Macro-scale Architectures in Collagen Hydrogels
Published on: February 12, 2016
Biodegradable and biocompatible collagen-based hybrid materials for force sensing applications
Mireia Andonegi1, Rafaela M Meira2, Daniela M Correia3
1BIOMAT Research Group, University of the Basque Country (UPV/EHU), Escuela de Ingeniería de Gipuzkoa, Plaza de Europa 1, 20018 Donostia-San Sebastián, Spain; Physics Centre of Minho and Porto Universities (CF-UM-UP) and Laboratory of Physics for Materials and Emergent Technologies, LapMET, University of Minho 4710-057, Braga, Portugal.
This study developed novel collagen films using ionic liquids for advanced applications. The films exhibit excellent electrical conductivity and non-cytotoxicity, making them suitable for sensitive force sensing applications.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Nanotechnology
Background:
- Synthetic macromolecules are widely used in advanced applications.
- There is a growing need for sustainable, biocompatible alternatives.
- Collagen, a natural macromolecule, offers potential for such applications.
Purpose of the Study:
- To develop collagen-based films with tunable electrical properties.
- To investigate the effect of ionic liquids on collagen film characteristics.
- To evaluate the suitability of these films for force sensing applications.
Main Methods:
- Collagen films were prepared by casting with varying concentrations (0-6 wt%) of two ionic liquids: choline dihydrogen phosphate ([Ch][DHP]) and choline serinate ([Ch][Seri]).
- Morphological, thermal, and electrical properties (direct current conductivity) were analyzed.
- Cytotoxicity was assessed using cell activity assays.
- Force sensing capabilities were evaluated through repeated testing.
Main Results:
- Film morphology and thermal properties were unaffected by ionic liquid type or content.
- The highest direct current electrical conductivity (1.4 × 10⁻⁸ S·cm⁻¹) was observed in collagen films with 3 wt% [Ch][DHP].
- IL/collagen films demonstrated non-cytotoxicity, with cell activity >70%.
Conclusions:
- Ionic liquids can modulate the electrical properties of collagen films without altering their morphology or thermal stability.
- Collagen films incorporating [Ch][DHP] show promising electrical conductivity for potential applications.
- These biocompatible collagen films are suitable for sensitive and stable force sensing applications.
