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Selective C(sp3)-H arylation/alkylation of alkanes enabled by paired electrocatalysis
Long Zou1, Siqi Xiang1, Rui Sun1
1The Institute for Advanced Studies (IAS), Wuhan University, Wuhan, Hubei, 430072, P. R. China.
Abstract:
We report a combination of electrocatalysis and photoredox catalysis to perform selective C(sp3)-H arylation/alkylation of alkanes, in which a binary catalytic system based on earth-abundant iron and nickel is applied. Reaction selectivity between two-component C(sp3)-H arylation and three-component C(sp3)-H alkylation is tuned by modulating the applied current and light source. Importantly, an ultra-low anodic potential (~0.23 V vs. Ag/AgCl) is applied in this protocol, thus enabling compatibility with a variety of functional groups (>70 examples). The robustness of the method is further demonstrated on a preparative scale and applied to late-stage diversification of natural products and pharmaceutical derivatives.
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