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Atorvastatin improves sputum conversion and chest X-ray severity score.

O O Adewole1, B A Omotoso2, M Ogunsina3

  • 1Department of Medicine, Obafemi Awolowo University, Ile Ife, Department of Medicine, Obafemi Awolowo University Teaching Hospitals Ile Ife.

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
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This study found that atorvastatin, when added to standard anti-tuberculosis (TB) drugs, is safe and improves treatment outcomes. Patients receiving atorvastatin showed better microbiological and radiological results in treating TB.

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Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Clinical Trials

Background:

  • Investigates the safety and efficacy of atorvastatin in combination with standard anti-tuberculosis (TB) drugs.
  • Focuses on treatment-naïve patients with uncomplicated pulmonary TB.

Purpose of the Study:

  • To evaluate the safety and effectiveness of adding atorvastatin to standard TB treatment.
  • To assess microbiological and radiological outcomes in TB patients.

Main Methods:

  • Phase IIB, multicentre, open-label, randomized study.
  • 150 participants assigned to standard care or standard care plus atorvastatin (40 mg daily for 2 months).
  • Primary endpoints: safety (severe adverse events) and effectiveness (negative sputum culture); Secondary endpoint: chest X-ray (CXR) severity score.

Main Results:

  • Adverse event severity was comparable between groups; muscle pain was more frequent in the atorvastatin group (16% vs. 5%).
  • Higher culture-negative rates in the atorvastatin group (97% vs. 85.1%, P=0.02).
  • Greater reduction in CXR severity score in the atorvastatin group (37% vs. 22%).

Conclusions:

  • Atorvastatin is a safe adjunct therapy for tuberculosis.
  • Atorvastatin demonstrates improved microbiological and radiological outcomes in TB patients.
  • Supports the use of atorvastatin to enhance standard anti-TB drug regimens.