Amyloidosis and Considerations for the Hand Surgeon.

Area of Science:

• Orthopedics
• Rheumatology
• Nephrology

Background:

• Amyloidosis is a systemic disease that can cause multiorgan failure.
• New treatments improve survival but require early diagnosis.
• Hand surgery manifestations may precede systemic diagnosis.

Purpose of the Study:

• To review amyloidosis pathophysiology and subtypes relevant to hand surgeons.
• To provide guidance on diagnosis, biopsy, and referral for patients with amyloidosis.
• To offer an overview of amyloidosis treatments and their impact.

Main Methods:

• Literature review of amyloidosis pathophysiology and clinical manifestations.
• Analysis of diagnostic opportunities in hand surgery.
• Summary of current treatment strategies.

Main Results:

• Carpal tunnel syndrome, trigger finger, neuropathy, and distal biceps rupture are key indicators.
• These hand conditions can predate systemic amyloidosis diagnosis.
• Early detection allows for timely intervention and improved outcomes.

Conclusions:

• Hand surgeons play a crucial role in the early detection of amyloidosis.
• Prompt diagnosis and referral can alter the disease course and improve survival.
• Understanding hand manifestations is vital for managing systemic amyloidosis.