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Updated: Jul 9, 2025
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Fabrication of Carbon Nanotube High-Frequency Nanoelectronic Biosensor for Sensing in High Ionic Strength Solutions
Published on: July 22, 2013
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Exploring novel electroanalytical approach using MWCNT nanostructures to quantify nimodipine.
1Redox Processes Research Center (CiPRex) and Organic and Physical Chemistry Department, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Postal Code 838492, Santiago, Chile.
Talanta
|December 3, 2023
Summary
Researchers developed a novel electrochemical sensor using buckypaper modified with multiwalled carbon nanotubes to detect Nimodipine (NMD) drug. This sensor successfully determined NMD in commercial tablets with high accuracy and sensitivity.
Area of Science:
- Electrochemistry
- Materials Science
- Pharmaceutical Analysis
Background:
- Nimodipine (NMD) is a drug with electroactive functional groups (nitroaromatic and dihydropyridine).
- Electrochemical sensors offer sensitive and selective detection methods for pharmaceuticals.
Purpose of the Study:
- To develop and validate a novel electrochemical sensor for Nimodipine (NMD) detection.
- To utilize buckypaper (BP) composed of multiwalled carbon nanotubes (MWCNT) for sensor fabrication.
Main Methods:
- Fabrication of glassy carbon electrodes (GCE) and screen-printed electrodes (SPE) modified with BP-MWCNT.
- Development of amperometric and voltammetric (DPV, linear voltammetry) detection strategies based on NMD's redox properties.
- Application of Batch Injection Analysis Cell (BIAS) for SPE-based detection.
Main Results:
- The BP-MWCNT modified electrodes effectively adsorbed and detected NMD.
- The sensor achieved high recovery (98.24%) and low detection/quantification limits (7.01 mgL⁻¹ and 23.35 mgL⁻¹ using DPV).
- Successful determination of NMD in commercial pharmaceutical tablets.
Conclusions:
- A sensitive and reliable electrochemical sensor for Nimodipine (NMD) was successfully developed.
- The BP-MWCNT composite material is a promising platform for electrochemical sensing applications.
- The developed sensor demonstrates practical utility for pharmaceutical analysis.
