Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Analgesia and Pain Management

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

Substance Use Disorders Affecting Sleep

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...

Desensitization and Tachyphylaxis

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.

Prescription, Nonprescription and Orphan Drugs

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...

Drugs Used in Upper Respiratory Disorders: Overview

Drugs Used in Upper Respiratory Disorders: Overview

Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...

Stress and Mental Health

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Kidney disease increases the risk of cardiovascular events in patients with device-detected atrial fibrillation: NOAH-AFNET 6.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026

Same author

Drugs for Migraine Prophylaxis.

Deutsches Arzteblatt international·2026

Same author

Moderate to Severe Acute Migraine Attacks: An Opinion Paper on the Use of Triptans and Triptan-NSAIDs Combinations in Individualized Treatment Plans.

Neurology and therapy·2025

Same author

Dopamine and prolactin in migraine: Mechanisms and potential therapeutic targets.

Journal of neuroendocrinology·2025

Same author

Effects of anticoagulation in patients with device-detected atrial fibrillation and multiple stroke risk factors: a win ratio analysis of the NOAH-AFNET 6 trial.

European heart journal. Quality of care & clinical outcomes·2025

Same author

PACAP and migraine.

Brain : a journal of neurology·2025

Search research articles

Related Experiment Video

Updated: Jul 9, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Chronic migraine and medication overuse.

Hans Christoph Diener¹, Paul Rizzoli²

¹Department of Neuroepidemiology, Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), Medical Faculty of the University Duisburg-Essen, Essen, Germany.

Handbook of Clinical Neurology

|December 3, 2023

Summary

Chronic migraine affects 1-3% globally and is influenced by medication overuse. Treatments include preventive medications and CGRP monoclonal antibodies, which are effective for chronic migraine with or without medication overuse.

Keywords:

CGRP monoclonal antibodies Chronic migraine Convergence theory Medication overuse headache Periaqueductal gray

More Related Videos

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

Related Experiment Videos

Last Updated: Jul 9, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

Area of Science:

Neurology
Headache Medicine

Background:

Chronic migraine, recognized since the 17th century, remains a significant diagnostic challenge with substantial societal impact.
Affecting 1-3% worldwide, patients with chronic migraine often transition between episodic and chronic phases.
Pathogenesis theories are evolving, supported by recent neuroimaging and clinical findings.

Purpose of the Study:

To review the current understanding of chronic migraine, including its prevalence, pathogenesis, and management.
To highlight modifiable factors contributing to the progression of episodic migraine to chronic migraine.
To discuss established and emerging therapeutic strategies for chronic migraine.

Main Methods:

Literature review of chronic migraine prevalence, pathophysiology, and treatment options.
Analysis of factors contributing to migraine chronification, with a focus on medication overuse.
Evaluation of the efficacy of various preventive treatments, including CGRP monoclonal antibodies.

Main Results:

Medication overuse is identified as a key modifiable factor in the progression to chronic migraine.
Established preventive treatments include topiramate, valproate, and onabotulinumtoxinA.
CGRP monoclonal antibodies demonstrate efficacy in managing chronic migraine, irrespective of medication overuse status.

Conclusions:

Chronic migraine is a complex neurological disorder with significant global prevalence.
Addressing medication overuse is crucial for managing chronic migraine.
CGRP monoclonal antibodies represent a promising therapeutic advance for chronic migraine management.