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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
[Application value of arousal threshold in obstructive sleep apnea]
1Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China.
Abstract:
The pathogenesis of obstructive sleep apnea (OSA) includes anatomical and non-anatomical factors, and the arousal threshold (ArTH) is one of the important non-anatomical factors. At present, the main method is to assess the increased respiratory effort due to arousal to determine the arousal threshold, and invasive epiglottic or esophageal manometry is the gold standard, while the non-invasive continuous positive airway pressure (CPAP) method and polysomnography (PSG) ventilation signal conversion method are also widely used. Arousal threshold is expected to serve as an important evaluation index and potential target for drug therapy in OSA, which is of great importance for realization of precise treatment of OSA. This article focused on the method and clinical significance of OSA arousal threshold.
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