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Published on: February 3, 2023
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[Development and Assessment of a New Oral Selenium Fast-disintegrating Tablets]
Keita Akagaki1, Aki Kadota1, Tomoaki Ishida1
1Department of Pharmacy, Kochi Medical School Hospital.
Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|December 3, 2023
Summary
A new fast-disintegrating selenium tablet was developed for patients needing supplementation. This formulation offers improved stability and easier administration via oral or feeding tube routes, enhancing patient quality of life.
Area of Science:
- Nutritional Biochemistry
- Pharmaceutical Sciences
- Materials Science
Context:
- Selenium is an essential trace element crucial for preventing conditions like myositis and myocardial damage.
- Patients on long-term parenteral or enteral nutrition are at high risk of selenium deficiency.
- Current selenium formulations in Japan face challenges with preservation and complex administration.
Purpose:
- To develop a novel, stable, and easily administrable fast-disintegrating selenium tablet formulation.
- To utilize SmartEx® (a D-mannitol, low substituted hydroxypropylcellulose, and fully hydrolyzed polyvinyl alcohol mixture) as a coprocessing additive.
- To ensure the formulation is suitable for both oral and feeding tube administration.
Summary:
- A new fast-disintegrating selenium tablet was created using SmartEx® coprocessing additive.
- The formulation demonstrated excellent disintegration, adequate hardness, and prevented tube blockage.
- Accelerated stability testing showed no property changes over 42 days without packaging.
Impact:
- The fast-disintegrating tablets offer a stable and convenient alternative for selenium supplementation.
- This innovation is expected to improve patient adherence and overall quality of life.
- Potential to simplify selenium therapy for individuals requiring long-term nutritional support.
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