Related Experiment Video
Updated: Jul 9, 2025

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes
Published on: April 19, 2024
Update on Focal Infection Management: A Czech Interdisciplinary Consensus
Vojtěch Peřina1, Roman Šmucler2, Petr Němec3
1Department of Oral and Maxillofacial Surgery, Masaryk University, Faculty of Medicine and University Hospital Brno, Brno, Czech Republic; Czech Dental Chamber, Prague, Czech Republic.
The oral-systemic axis links oral health to systemic diseases like diabetes and heart disease. A new algorithm helps healthcare workers manage these complex patient cases effectively.
Area of Science:
- Oral Health and Systemic Disease
- Microbiology and Immunology
- Evidence-Based Medicine
Background:
- The historical focal infection theory proposed oral infections cause systemic diseases.
- Modern understanding reveals a complex oral-systemic axis, linking oral microbiota to conditions like periodontal disease, diabetes, and cardiovascular disease.
- Existing management protocols for the oral-systemic axis vary across jurisdictions.
Purpose of the Study:
- To establish a consensus on the oral-systemic axis concept.
- To develop a standardized protocol for managing focal odontogenic infections and their systemic implications.
- To guide healthcare workers in patient management related to oral-systemic health.
Main Methods:
- A multidisciplinary team of specialists (dentistry, ENT, cardiology, orthopaedics, oncology, diabetology) was convened.
- The team's conceptual understanding of the focal infection theory and oral-systemic axis was assessed.
- A protocol was developed to evaluate the strength of oral-systemic associations and guide therapeutic interventions.
Main Results:
- Scoring algorithms were created to quantify odontogenic inflammatory diseases and associated systemic risks.
- Standardized procedures were developed for the management of oral-systemic conditions.
- The study facilitated a consensus among diverse medical specialties.
Conclusions:
- The developed oral-systemic axis algorithm provides a valuable tool for healthcare professionals.
- This algorithm aids in guiding patient management protocols for conditions influenced by the oral-systemic axis.
- It promotes a more integrated approach to managing oral health and its systemic consequences.
Related Concept Videos
Pleural Effusion II: Symptoms and Management
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Tonsillitis II: Management
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:

