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Ferulated Poly(vinyl alcohol) based hydrogels.

Simone Pepi1, Marco Paolino1, Mario Saletti1

  • 1Dipartimento di Biotecnologie, Chimica e Farmacia (Dipartimento di Eccellenza 2018-2022), Università Degli Studi di Siena, Via A. Moro 2, 53100, Siena, Italy.

Heliyon
|December 4, 2023
PubMed
Summary

New hydrogels made from poly (vinyl alcohol) and ferulic acid derivatives form strong, absorbent gels suitable for wound dressings. The best candidate hydrogel demonstrated excellent fluid absorption and mechanical stability for wound care applications.

Keywords:
Ferulic acidHydrogelRheologyWound dressingpoly(vinyl alcohol) (PVA)

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Wound Healing Technologies

Background:

  • Poly (vinyl alcohol) (PVA) is a versatile polymer with potential biomedical applications.
  • Ferulic acid (FA) derivatives offer crosslinking capabilities for hydrogel formation.
  • Developing advanced wound dressings requires materials with high fluid absorption and mechanical stability.

Purpose of the Study:

  • To synthesize novel graft copolymers of PVA and ferulic acid derivatives.
  • To investigate the hydrogel properties of these copolymers for wound dressing applications.
  • To identify the optimal formulation for wound dressing use.

Main Methods:

  • Graft copolymerization of PVA with ferulic acid derivatives via ester bond formation.
  • Rheological analyses to assess gel strength and properties.
  • Swelling kinetics and Moisture Vapour Transmission Rate (MVTR) measurements for fluid handling.
  • Mechanical testing including elasticity, compliance, stress-relaxation, and adhesion.

Main Results:

  • Strong hydrogels were successfully formed in water due to ferulic acid crosslinking.
  • The hydrogels exhibited significant fluid absorption and retention capabilities.
  • Mechanical assessments confirmed good elasticity, compliance, and adhesive properties.
  • Hydrogel PVA-FA2-3 showed the most promising characteristics for wound dressing applications.

Conclusions:

  • Graft copolymers of PVA and ferulic acid derivatives can form robust hydrogels.
  • These hydrogels possess desirable properties for advanced wound dressing materials.
  • The PVA-FA2-3 hydrogel is identified as a prime candidate for further development in wound care.